| 发明名称 |
Modified oligonucleotides for use in RNA interference |
| 摘要 |
The present invention provides modified oligonucleotides for use in the RNA interference pathway of gene modulation. At least one nucleoside has a 2'-modification other than hydroxyl that gives an RNA like 3'-endo sugar conformation. The modified oligonucleotides are also provided having a 5'-phosphate group.
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| 申请公布号 |
US2004203024(A1) |
申请公布日期 |
2004.10.14 |
| 申请号 |
US20030700697 |
申请日期 |
2003.11.04 |
| 申请人 |
BAKER BRENDA F.;ELDRUP ANNE B.;MANOHARAN MUTHIAH;BHAT BALKRISHEN;GRIFFEY RICHARD H.;SWAYZE ERIC E.;CROOKE STANLEY T. |
发明人 |
BAKER BRENDA F.;ELDRUP ANNE B.;MANOHARAN MUTHIAH;BHAT BALKRISHEN;GRIFFEY RICHARD H.;SWAYZE ERIC E.;CROOKE STANLEY T. |
| 分类号 |
A61K48/00;C07H21/02;C07H21/04;C12Q1/68;(IPC1-7):A61K48/00 |
主分类号 |
A61K48/00 |
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