发明名称 |
COMBINATION THERAPY OF ZD6474 WITH 5-FU OR/AND CPT-11 |
摘要 |
The present invention relates to a method for the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human, which is optionally being treated with ionising radiation, particularly a method for the treatment of a cancer, particularly a cancer involving a solid tumour, which comprises one of: the administration of ZD6474 in combination with 5-FU; the administration of ZD6474 in combination with CPT-11; and the administration of ZD6474 in combination with 5-FU and CPT-11; to a pharmaceutical composition comprising one of: ZD6474 and 5-FU; ZD6474 and CPT-11; and ZD6474 and 5-FU and CPT-11; to a combination product comprising one of: ZD6474 and 5-FU; ZD6474 and CPT-11; and ZD6474 and 5-FU and CPT-11, for use in a method of treatment of a human or animal body by therapy; to a kit comprising one of: ZD6474 and 5-FU; ZD6474 and CPT-11; and ZD6474 and 5-FU and CPT-11; to the use of one of: ZD6474 and 5-FU; ZD6474 and CPT-11; and ZD6474 and 5-FU and CPT-11, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation. |
申请公布号 |
WO2004071397(A3) |
申请公布日期 |
2004.10.14 |
申请号 |
WO2004GB00550 |
申请日期 |
2004.02.11 |
申请人 |
ASTRAZENECA AB;ASTRAZENECA UK LIMITED;WEDGE, STEPHEN, ROBERT;RYAN, ANDERSON, JOSEPH |
发明人 |
WEDGE, STEPHEN, ROBERT;RYAN, ANDERSON, JOSEPH |
分类号 |
A61K31/4745;A61K31/513;A61K31/517;A61P35/00 |
主分类号 |
A61K31/4745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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