发明名称 |
FADD PROTEINS, PHOSPHORYLATED P38-MAPK AND FASL AS TUMOUR MARKERS |
摘要 |
The application relates to the use of at least one protein selected from the group consisting of FADD proteins and phosphorylated p38-MAPK, as a marker for absence of in vivo tumour. This use may further be complemented by the use of the FasL protein as a marker for presence of in vivo tumour. The (respective) amount(s) of FADD proteins and phosphorylated p38-MAPK indeed decrease, sometimes up to zero, with tumour development, while FasL expression is gained. FADD proteins are secreted from out of the tumour cells into their extracellular environment. A low cellular amount and a high extracellular amount of FADD proteins are prognostic of resistance to chemotherapy. |
申请公布号 |
EP1466180(A2) |
申请公布日期 |
2004.10.13 |
申请号 |
EP20020796774 |
申请日期 |
2002.12.23 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LARECHERCHE MEDICALE (INSERM);CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
CHIOCCHIA, GILLES;TOURNEUR, LEA;FEUNTEUN, JEAN;MICHIELS, FRANCINE;BUZYN, AGNES |
分类号 |
C12N15/09;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/574;G01N33/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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