发明名称 |
Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV |
摘要 |
<p>The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit a protective immune response against HIV infection. Compositions, pharmaceutical compositions and vaccines comprising these antigenic peptides are also encompassed by the present invention, as well as neutralizing antibodies which inhibit infection of primary CD4+ T lymphocytes by various HIV isolates. Methods for diagnosis of HIV are also disclosed.</p> |
申请公布号 |
EP1466924(A1) |
申请公布日期 |
2004.10.13 |
申请号 |
EP20030290919 |
申请日期 |
2003.04.11 |
申请人 |
INSTITUT PASTEUR;CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
HOVANESSIAN, ARA;BRIAND, JEAN-PAUL;MULLER, SYLVIANE;KRUST, BERNARD;SVAB, JOSETTE;SAID, ELIAS |
分类号 |
A61K39/21;A61P31/18;C07K14/16;C07K16/10;G01N33/569;(IPC1-7):C07K16/10;G01N33/53 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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