| 发明名称 |
Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors |
| 摘要 |
<p>CETP Inhibitors have improved solubility and bioavailability in a lipophilic vehicle comprising a digestible oil, a lipophilic solvent, or a surfactant. Preferred such compositions are self-emulsifying or self-microemulsifying, and comprise 1. a CETP inhibitor; 2. a cosolvent; 3. a surfactant having an HLB of 1 to 8; 4. a surfactant having an HLB of over 8 to 20; and 5. optionally, a digestible oil.</p> |
| 申请公布号 |
CZ20033341(A3) |
申请公布日期 |
2004.10.13 |
| 申请号 |
CZ20030003341 |
申请日期 |
2002.05.03 |
| 申请人 |
PFIZER PRODUCTS INC. |
发明人 |
GUMKOWSKI MICHAEL JON;MURDANDE SHARAD BALASAHEB;PERLMAN MICHAEL ELLIS;LOMBARDO FRANCO |
| 分类号 |
C07D249/08;A61K9/10;A61K9/107;A61K9/48;A61K31/00;A61K31/015;A61K31/045;A61K31/255;A61K31/265;A61K31/41;A61K31/4196;A61K31/44;A61K31/4418;A61K31/47;A61K31/4706;A61K31/4709;A61K45/08;A61K47/10;A61K47/14;A61K47/22;A61K47/32;A61K47/34;A61K47/44;A61P3/06;A61P43/00;C07D213/30;C07D215/42;(IPC1-7):A61K47/44;A61K31/470;A61K31/419 |
主分类号 |
C07D249/08 |
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