| 发明名称 |
Silenced anti-CD28 antibodies and use thereof. |
| 摘要 |
The present invention provides anti-CD28 antibodies which are defective in mitogenic activity (silenced anti-CD28 antibodies), methods of producing, compositions containing the antibody and methods of immunosuppression, inducing T-cell tolerance and treating organ and/or tissue transplant rejections. |
| 申请公布号 |
ZA200305384(B) |
申请公布日期 |
2004.10.11 |
| 申请号 |
ZA20030005384 |
申请日期 |
2003.07.11 |
| 申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD. |
发明人 |
J. YUN TSO;MAXIMILIANO VASQUEZ;YASUYUKI HIGASHI;HIROTSUGU UEDA;PAUL HINTON;KOUICHI TAMURA;NOBUO SEKI |
| 分类号 |
C12N15/09;A61K39/00;A61K39/395;A61K45/00;A61P37/00;A61P37/06;A61P41/00;A61P43/00;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08;G01N33/53 |
主分类号 |
C12N15/09 |
| 代理机构 |
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