发明名称 |
STEROID SPIROLACTONIZATION |
摘要 |
A steroid comprising a 17-spirolactone or corresponding open lactone structu re is obtained by carbonylation of a 17-alkenyl or 17-alkynyl substrate. A 17- alkenyl intermediate may be prepared by semi-hydrogenation of a 17-alkynyl group. Multiple reaction schemes are disclosed for preparation of a 3-keto- 9,11-epoxy-17-spirolactone steroid such as eplerenone. Novel intermediates a re also disclosed, as well as steps for forming such novel intermediates, or converting them to further intermediates or products, by semi-hydrogenation, carbonylation, 6,7-dehydrogenation, furylation or other transformations or combinations thereof.
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申请公布号 |
CA2519770(A1) |
申请公布日期 |
2004.10.07 |
申请号 |
CA20042519770 |
申请日期 |
2004.03.22 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
FRANCZYK, THADDEUS S., II;WAGNER, GRACE M.;MACKEY, SONJA S.;HAVENS, JEFFREY L.;WU, HAIFENG;PEARLMAN, BRUCE ALLEN;PADILLA, AMPHLETT GREGG |
分类号 |
C07J75/00;C07D307/94;C07J;C07J1/00;C07J9/00;C07J19/00;C07J71/00 |
主分类号 |
C07J75/00 |
代理机构 |
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主权项 |
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