METHODS OF DETECTING NEUROLOGICAL DISORDERS

摘要

The present invention provides methods of detecting an amyloid peptide-relat ed neurological disorder in an individual; and methods for staging an amyloid peptide-related neurological disorder in an individual. The methods involve detecting a level of a calcium-responsive gene product, such as calbindin, i n a hippocampal neuron, especially a granule cell of the dentate gyrus. The invention further provides identifying an agent that treats an amyloid pepti de- related neurological disorder, as well as agents identified by the methods.< /SDOAB>