| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a new MMP (matrix metalloprotease)-3 inhibitor which has an excellent MMP-3-inhibiting activity and is useful as a medicine capable of efficiently preventing and treating diseases such as chronic articular rheumatism, hypertrophic arthritis, diabetic ulcer, decubitus, ulcerative colitis, duodenal ulcer, dermatitis herpetiformis, and cancer. <P>SOLUTION: This MMP-3 inhibitor is characterized by containing a propenohydroxamic acid derivative represented by general formula (1) [R<SP>1</SP>is H, an alkyl, or the like; R<SP>2</SP>is a cycloalkyl, an aryl which may have one or more substituents, or the like; R<SP>3</SP>is H or a halogen; R<SP>4</SP>is H or an alkyl which may have one or more substituents; R<SP>5</SP>is R<SP>6</SP>CO, R<SP>6</SP>SO<SB>2</SB>, R<SP>6</SP>CONH, or R<SP>6</SP>CSNH (R<SP>6</SP>is an alkyl or cycloalkyl which may have one or more substituents, or the like); R<SP>7</SP>is H or a protecting group; A is CH or N] or its salt. <P>COPYRIGHT: (C)2005,JPO&NCIPI</p> |
