SOLID ORAL DOSAGE FORM CONTAINING SEAMLESS MICROCAPSULES

摘要

This invention relates to a solid oral dosage form containing one or more pharmaceutically active ingredients solubilised or suspended in a pharmaceutically acceptable solvent or liquid phase and encapsulated in seamless controlled release microcapsules. Accordingly the pharmaceutically acceptable solvent or liquid phase may range from aqueous phase, organic solvent(s), glycols, oils and derivatives of including mono-,di, and trigycerides of short, medium and long chain fatty acids. The microcapsules have a diameter of <1mm to 8mm and a drug loading of up to 90%. Additionally the microcapsules may be coated to release the pharmaceutically active ingredient at specific sites and for predetermined rates.