摘要 |
<p>A method is provided for using alpha2delta subunit calcium channel modulators or other compounds that interact with the alpha2delta calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, alpha2delta subunit calcium channel modulators include GABA analogs (e.g. gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, ß3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.</p> |
申请人 |
DYNOGEN PHARMACEUTICALS, INC.;FRASER, MATTHEW, OLIVER;THOR, KARL, BRUCE;BURGARD, EDWARD, C.;BRETTMAN, LEE, R.;LANDAU, STEVEN, B.;RICCA, DANIEL, J. |
发明人 |
FRASER, MATTHEW, OLIVER;THOR, KARL, BRUCE;BURGARD, EDWARD, C.;BRETTMAN, LEE, R.;LANDAU, STEVEN, B.;RICCA, DANIEL, J. |