| 发明名称 |
GENETIC DIAGNOSIS OF HYPERTENSION OR HYPOTENSION UTILIZING POLYMORPHISM IN MATRIX METALLOPROTEINASE 9 GENE AND NUCLEIC ACID MOLECULE USED THEREFOR |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for genetic diagnosis of hypertension or hypotension in females. <P>SOLUTION: A codon encoding alanine in Ala20Val polymorphism in a matrix metalloproteinase 9 gene is used as a risk factor for the hypertension in the females. Furthermore, a T allele in C(-1562) T polymorphism and a codon encoding glutamine in Arg668Gln polymorphism are used as the risk factor for the hypotension in the females. <P>COPYRIGHT: (C)2005,JPO&NCIPI |
| 申请公布号 |
JP2004275007(A) |
申请公布日期 |
2004.10.07 |
| 申请号 |
JP20030066779 |
申请日期 |
2003.03.12 |
| 申请人 |
NATIONAL CARDIOVASCULAR CENTER;IYAKUHIN FUKUSAYOU HIGAI KYUUSAI KENKYU SHINKO CHOSA KIKO |
发明人 |
KOKUBO YOSHIHIRO;MANNAMI TOSHIBUMI;MIYATA TOSHIYUKI;TOMOIKE MASANOBU |
| 分类号 |
G01N33/53;C12N15/09;C12Q1/68 |
主分类号 |
G01N33/53 |
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