发明名称 |
IDENTIFICATION, QUANTIFICATION, AND CHARACTERIZATION OF T CELLS AND T CELL ANTIGENS |
摘要 |
Methods of quantifying and/or characterizing antigen-specific T cell populations, identifying T cell antigens and epitopes, and preparing targeted pharmaceutical compositions by (i) introducing a peptide into an antigen-presenting cell (APC) expressing a fusion protein comprising a major histocompatibility complex portion and a reporter peptide portion such that a complex forms between the fusion protein and the peptide and the peptide is displayed by the APC and (ii) contacting the APC with a population of cells, such that T cells in the population of cells that react with the peptide detectably internalize the complex; novel APCs useful in such methods; and related therapeutic and diagnostic methods. |
申请公布号 |
WO2004084838(A2) |
申请公布日期 |
2004.10.07 |
申请号 |
WO2004US08960 |
申请日期 |
2004.03.24 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;JACOBSON, STEVEN;TAKEUCHI, UTANO;YAMANO, YOSHIHISA |
发明人 |
JACOBSON, STEVEN;TAKEUCHI, UTANO;YAMANO, YOSHIHISA |
分类号 |
A61K;C12N5/10;G01N33/53;G01N33/566;G01N33/569 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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