NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

摘要

Compounds represented by formula (I): wherein R<1> is H, halogen, (C1-4) alkyl, O(C1-4) alkyl, and haloalkyl; R<2> is H or (C1-4)alkyl; R<3> is H or (C1-4) alkyl; R<4> is (C1.4)alkyl, (C1-4)alkyl(C3.7) cycloalkyl, or (C3_7) cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1.4) alkyl which in turn maybe optionally substituted with pyridinyl-N­oxide or C(O) OR wherein R is H or (C1-4) alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.