1,4-DISUBSTITUTED PIPERIDINE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME

摘要

PROBLEM TO BE SOLVED: To obtain a compound which exhibits strong affinity with a serotonin 4 receptor and is useful as an enterokinesis-stimulating medicine or enterokinesis-improving medicine. SOLUTION: The compound represented by formula (I) äAr is a group represented by formula (Ar-1) or (Ar-2) [R1is a halogen atom; R2is H, or the like; R3is H, or the like; R4is H, or the like; R5and R6are each identically or differently H, or the like; (h) is 1, or the like]; Z is CO, or the like; A is a group of formula (A-1) or (A-2) [R7and R8are each a lower alkenyl, or the like; (p)+(q) is an integer of 1 to 7; Q is CH2, or the like; R9and R10are each a lower alkyl, or the like]} or its physiologically acceptable acid adduct salt is provided. COPYRIGHT: (C)2005,JPO&NCIPI