PROCESS, REACTOR AND SAMPLING DEVICE

摘要

A method for carrying out a solid-phase synthesis in a variable volume reactor, also a sampling device and a variable volume reactor. The variable volume reactor (1) comprises a cylinder shaped housing (2) containing a solid-phase support (3) and having a static sinter at one end (4) and a moveable sinter at the other end (5) each having an associated support (6, 7). The sinters are held in the column by end pieces that are screwed on to the column (8, 9). The moveable sinter has an associated piston (10). The reactor further comprises a solvent inlet (12) and a solvent outlet (11). A pressure sensor (13) is positioned in the static sinter support (6). The piston (10) is in threaded connection (14, 15) with a drive ring (16) held in place with bearings (17, 18) by the end piece (9).