发明名称 |
REDUCTION OF ZINC-INDUCED NEUROTOXIC INJURY BY BLOCKADE OF NITRIC OXIDE SYNTHESIS |
摘要 |
The present invention provides methods of inhibiting release of zinc from neurons and of preventing zinc-mediated brain injury. Also provided are methods of improving cerebral blood flow while preventing zinc-mediated brain injury. Inhibitors of or activators of nitric oxide synthases modulate nitric oxide synthesis to reduce nitric oxide-induced release of neurotoxic amounts of zinc, thereby reducing zinc-mediated neuronal injury after brain trauma. |
申请公布号 |
WO2004084827(A2) |
申请公布日期 |
2004.10.07 |
申请号 |
WO2004US08619 |
申请日期 |
2004.03.22 |
申请人 |
NEUROBIOTEX, INC. |
发明人 |
FREDERICKSON, CHRISTOPHER, J. |
分类号 |
A61K;A61K31/155;A61K31/195;A61K31/198;A61K31/415;A61K31/54;A61K38/05 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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