发明名称 |
HBM VARIANTS THAT MODULATE BONE MASS AND LIPID LEVELS |
摘要 |
The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis. |
申请公布号 |
WO02092000(A3) |
申请公布日期 |
2004.10.07 |
申请号 |
WO2002US14877 |
申请日期 |
2002.05.13 |
申请人 |
GENOME THERAPEUTICS CORPORATION;WYETH;ALLEN, KRISTINA;ANISOWICZ, ANTHONY;GRAHAM, JAMES, R.;MORALES, ARTURO;YAWORSKY, PAUL, J.;LIU, WEI |
发明人 |
ALLEN, KRISTINA;ANISOWICZ, ANTHONY;GRAHAM, JAMES, R.;MORALES, ARTURO;YAWORSKY, PAUL, J.;LIU, WEI |
分类号 |
A01K67/027;A61K35/00;A61K38/00;A61K39/395;A61K45/00;A61P3/00;A61P19/00;A61P19/10;C07K14/47;C07K14/51;C07K16/18;C12N5/10;C12N15/09;C12N15/12;C12N15/85;C12P21/08;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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地址 |
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