发明名称 |
Method for producing (R) -3- [4- (trifluoromethyl) phenylamino] -pentanoic acid amide derivative |
摘要 |
The present invention provides a method for easily producing an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative useful for an intermediate for pharmaceutical products, particularly an inhibitor of a cholesteryl ester transfer protein (CETP) from easily available raw materials. In the present invention, (S)-N-[4-(trifluoromethyl)phenyl]-3-hydroxypentanoic acid amide prepared from easily available raw materials leads a production of (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone to give (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide. Furthermore, (R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone is reacted with a carbamic acid ester to give an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative.
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申请公布号 |
US2004199005(A1) |
申请公布日期 |
2004.10.07 |
申请号 |
US20040801141 |
申请日期 |
2004.03.16 |
申请人 |
KANEKA CORPORATION |
发明人 |
TANAKA TATSUYOSHI;SUGAWARA MASANOBU;MAEDA HIROFUMI;NISHIYAMA AKIRA;YOSHOHARA YOSHIHIKO;NAGASHIMA NOBUO |
分类号 |
C07C231/02;C07C309/66;C07C309/73;C07D205/08;(IPC1-7):C07C269/02 |
主分类号 |
C07C231/02 |
代理机构 |
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