Means and method for hormonal contraception

摘要

The present invention is concerned with a kit containing a plurality of hormone units for use in a contraceptive method which consists of three alternating consecutive phases, sometimes referred to as a sequential method or sequential regimen. More particularly the present invention relates to a kit containing a plurality of daily hormone units for use in a contraceptive method which consists of three consecutive phases-an estrogenic, a progestogenic and a hormone-free phase-said method comprising administering to a female of childbearing capability a) during the estrogenic phase one or more hormone units to provide a therapeutically effective amount of synthetic estrogen or a combination of synthetic estrogen and biogenic estrogen to inhibit ovulation and (b) during the progestogenic phase one or more hormone units to provide a combination of biogenic estrogen and progestogen in a therapeutically effective amount to inhibit ovulation and to transform the endometrium from a proliferative into a secretory state, wherein the progestogenic phase encompasses a period of at least 10 days, the hormone-free phase encompasses a period of at least 1 day and the three consecutive phases together encompass a period of 20-35 days.