CELL DEATH-INDUCING FUSED GENE ACTING SPECIFICALLY ON CANCERAND GENE PRODUCT THEREOF

摘要

It is intended to provide a protein having a potent effect of inducing cell death (i.e., a fused protein having a denatured Bax protein carrying GEP fus ed to the N-terminal and a homing signal peptide having a homing effect on canc er cells further fused in the N-terminal side); a gene encoding the fused protein; and a cancer cell proliferation inhibitor containing the fused protein. Namely, a fused gene containing a cell death-inducing gene specifically acting on cancer cells, which is a fused gene having a gene encoding a cancer cell-specific homing signal peptide sequence, a gene encoding a green fluorescent protein (GFP) and a gene encoding .DELTA.-NBax with a deletion of the N-terminal sequence containing BH3 region of human Ba x in this order, and a fused protein encoded by the fused gene.