SOLID LIPID NANOPARTICLE CONTAINING LIPOPHILIC LIPID AND AMPHIPHILIC LIPID, PHARMACEUTICAL COMPOSITION CONTAINING THE SOLID LIPID NANOPARTICLE FOR DELIVERING THE ACTIVE SUBSTANCE AND PREPARING METHOD THEREOF

摘要

PURPOSE: Provided are a solid lipid nanoparticle containing lipophilic lipid and amphiphilic lipid and having a particle size of 500nm, preferably 100nm or less, a pharmaceutical composition containing the solid lipid nanoparticle for delivering the active substance and a preparing method thereof. CONSTITUTION: The solid lipid nanoparticle is characterized by containing lipophilic lipid and amphiphilic lipid and having a particle size of 500nm, preferably 100nm or less, wherein the lipophilic lipid is hard fat or wax having a melting point of 40 deg.C, and the amphiphilic lipid is polyethyleneglycol(PEG) bound hard fat or wax having a melting point of 40 deg.C. The pharmaceutical composition contains 20 wt.% of lipophilic lipid, amphiphilic lipid, water insoluble substance and dispersant, based on the total weight of the composition.