| 摘要 |
An ergoline derivative of formula 1: <CHEM> wherein: X is C=NH, C=O, C=S, PO2 or SO2; R<1> is C1-7 alkyl, C3-7 cycloalkyl, optionally substituted or heterocyclic fused phenyl, alkylamino or dialkylamino, R2 NC(S)NH, alkoxy and alkylthio; R<2> is H, C1-5 alkyl or C3-5 alkenyl; R<3> is H, F, Cl, Br, I, CN, Me, CHF2 or CF3; R<4> is H or C1-4 alkyl; <??>9, 10 position are dihydro- (as shown in formula 1), didehydro-, dihydroxy-, hydroxyhalo- (unsaturated), epoxy-, dihalo-, hydrohalo-, hydrohydroxy- or CAB (A, B is halogen or hydrogen) adducts; and acid addition and metal salts thereof.
|
