发明名称 |
Novel anthracycline prodrugs, method for preparation as well as their use in selective chemotherapy |
摘要 |
Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula <CHEM> as well as the acid addition salts thereof. Further the synthesis of these derivatives and their use, alone or in combination with enzymes or antibody enzyme conjugates are disclosed. |
申请公布号 |
EP0751144(B1) |
申请公布日期 |
2004.10.06 |
申请号 |
EP19950201747 |
申请日期 |
1995.06.27 |
申请人 |
PHARMACHEMIE B.V. |
发明人 |
LEENDERS, RUBEN GERARDUS GEORGE;DAMEN, ERIC WILHELMUS PETRUS;SCHEEREN, JOHAN WILHELM;HAISMA, HIDDE JACOB;HOUBA, PIETER HERMAN JOHANNES;DE VOS, DICK |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K39/395;A61P35/00;C07F7/18;C07H15/203;C07H15/252 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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