发明名称 |
Variants of native growth hormones having non naturally occurring amino acid sequences or covalent modifications |
摘要 |
Growth hormones contain two receptor binding sites termed site 1 and site 2 with which they form ternary complexes with their receptors. In this scheme, site 1 on the hormone binds to one molecule of receptor and then site 2 binds to another molecule of receptor, thereby producing a 1:2 complex. Disclosed herein are growth hormone variants consisting of modifications to the native sequence in the region of site 1 or site 2, or alternatively a combination of modifications at both site 1 and site 2.
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申请公布号 |
US6800740(B1) |
申请公布日期 |
2004.10.05 |
申请号 |
US19950479883 |
申请日期 |
1995.06.07 |
申请人 |
GENENTECH, INC. |
发明人 |
CUNNINGHAM BRIAN C.;WELLS JAMES A. |
分类号 |
A01K67/027;A61K38/00;A61K38/04;A61K39/395;A61P5/02;A61P5/06;A61P43/00;C07K14/505;C07K14/52;C07K14/53;C07K14/535;C07K14/54;C07K14/545;C07K14/55;C07K14/555;C07K14/56;C07K14/565;C07K14/575;C07K14/61;C07K14/705;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12N15/85;C12P21/02;G01N33/15;G01N33/50;G01N33/53;G01N33/542;G01N33/68;G01N33/74;(IPC1-7):A61K38/27;C07K14/475 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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