发明名称 |
NOVEL SELECTIVE BRADYKININ (BK) B1 PEPTIDIC RECEPTOR ANTAGONISTS AND USES THEREOF |
摘要 |
The present invention provides for a novel peptidic antagonist for the bradykinin B1 (BKB1) receptor having very good to excellent affinities and selectivity for the BKB, receptor, in vitro and in vivo increase resistance to enzymatic degradation, superior pharmacokinetic properties, capability to significantly reduce microvascular leakage observed alongside diabetic-induced increase in vascular permeability, capability to significantly reduced the state of hyperalgesia alongside diabetes, capability to significantly reduce the infiltration of pro- inflammatory cells and general state of inflammation alongside allergic asthma.
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申请公布号 |
CA2423876(A1) |
申请公布日期 |
2004.10.01 |
申请号 |
CA20032423876 |
申请日期 |
2003.04.01 |
申请人 |
UNIVERSITE DE SHERBROOKE |
发明人 |
SIROIS, PIERRE;REGOLI, DOMENICO;GOBEIL, FERNAND;NEUGEBAUER, WITOLD A.;GABRA, BICHOY |
分类号 |
A61K38/00;C07K7/18;(IPC1-7):C07K7/06;A61K38/08;A61P3/10;A61P11/06;A61P29/00 |
主分类号 |
A61K38/00 |
代理机构 |
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