Enantioselective oxidation of sulfides to form sulfoxides, especially tenatoprazole, using an oxidizing agent in the presence of a tungsten or vanadium-based catalyst and a chiral ligand

摘要

Enantioselective process for the preparation of sulfoxide derivatives and their salts comprises enantioselective oxidation of a sulfide (I) using an oxidizing agent in the presence of a tungsten or vanadium-based catalyst and a chiral ligand, optionally followed by salification to give the sulfoxide (Ia). Enantioselective process for the preparation of sulfoxide derivatives and their salts comprises enantioselective oxidation of a sulfide A-CH 2-S-B (I) using an oxidizing agent in the presence of a tungsten or vanadium-based catalyst and a chiral ligand, optionally followed by salification to give the sulfoxide A-CH 2-SO-B (Ia). A : a substituted pyridyl ring; B : a heterocyclic residue having an benzimidazole or imidazo-pyridyl ring. ACTIVITY : Gastrointestinal-Gen. MECHANISM OF ACTION : Proton Pump Inhibitor.