RADIOPHARMACEUTICALS FOR CANCER DIAGNOSIS AND TREATMENT

摘要

Radionuclide labelled conjugates based on substance P and analogues thereof with the chelator (DOTAGA) (1 -(1 -rarboxy-3-carboxy-propyl)-4,7, 10(carboxymethyl)- 1,4,7,10-tetraazacyclo-dodecane, DOTASA (1 -(1 -carboxy-2­carboxy-ethyl)-4,7, 10 (carboxymethyl)1,4,7, 10-tetraazacyclo-dodecane, or chelator (DOTA) [1,4,7, 10 ­tetraazaacyclo-dodecane1,4,7, 1 0-tetra(acetie acid)] are useful rad iopharmaceutical substa nces for targeting and treatment of brain tumors, especially gliomas.