REMEDY FOR PERIODONTAL DISEASE

摘要

It is intended to provide a human monoclonal antibody (preferably a monoclonal antibody to 40-kDa OMP inhibiting the binding to hemin) which has an activity of inhibiting aggregation of the periodontal disease bacterium and an activity of promoting the bactericidal effect of leukocytes without any risk of side effects, etc., and a drug against periodontal disease which contains the above monoclonal antibody. Namely, an antibody binding to 40-kDa OMP which has at least one of the following activities: (1) an activity of inhibiting the co-aggregation of P. gingivalis; (2) an activity of phagocytosis of human neutrophils; and (3) an activity of inhibiting the binding of 40-kDa OMP to hemin; or a functional fragment of the antibody.