| 摘要 |
PROBLEM TO BE SOLVED: To provide an improved method for synthesizing ecteinascidin 743 of an antitumor active substance. SOLUTION: The improved technique for synthesizing ecteinascidin 743 uses a compound of formula 1 (wherein R<SB>1</SB>and R<SB>3</SB>are each H or a≤4C alkyl group; R<SB>2</SB>is an alkoxyxcarbonyl group, a lower alkylsulfonyl group, an arylsulfonyl group or H; X<SB>1</SB>is a phenylsilyl group which may have a≤4C alkyl group and/or an electron-donating group; X<SB>2</SB>is H, a≤4C alkyl group, an alkoxyalkyl group, an allyl group or an alkyl or arylsulfonyl group; Y is O or N) and a compound of formula 2 (wherein R<SB>3</SB>, X<SB>1</SB>, and Y are the same as defined above) as synthetic intermediates. COPYRIGHT: (C)2004,JPO&NCIPI
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