发明名称 |
METHODS AND COMPOSITIONS FOR PREVENTING/REDUCING THE SEVERITY OF SIDE EFFECTS OF CHEMOTHERAPY AND/OR RADIOTHERAPY |
摘要 |
A method of inhibiting cell cycle progression by administering to a subject an effective amount of a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor is disclosed. More particularly, the specification discloses the use of a HMG-CoA reductase inhibitor to prevent or reduce the severity of epithelial cytotoxicity side-effects, such as alopecia, mucositis and/or plantar-palmar syndrome in a subject receiving chemotherapy and/or radiotherapy. The HMG-CoA reductase inhibitor is preferably a statin or a derivative, analogue or prodrug thereof.
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申请公布号 |
WO2004062659(A8) |
申请公布日期 |
2004.09.30 |
申请号 |
WO2004AU00041 |
申请日期 |
2004.01.13 |
申请人 |
MAYNE PHARMA PTY LTD;SETIAWAN, KERRIE;SMITH, IAN, KEITH |
发明人 |
SETIAWAN, KERRIE;SMITH, IAN, KEITH |
分类号 |
A61K31/35;A61K45/06;A61P17/14;A61P39/00;(IPC1-7):A61K31/35 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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