METHOD FOR PREPARING SMALL PARTICLES

摘要

The present invention is concerned with the formation of small particles or organic compounds by precipitating the organic compounds in an aqueous mediu m to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water- miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding ener gy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 .mu.m. The process is preferably used to prepare a suspension of small particles of a poorly water - soluble, pharmaceutically active compound suitable for in vivo delivery by a n administrate route such as parenteral, oral, pulmonary, nasal, buccal, topic al ophthalmic, rectal, vaginal, transdermal or the like.