DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH COMPLEMENT COMPONENT 5A RECEPTOR (C5AR)

摘要

The invention provides a human C5AR which is associated with the cardiovascular disorders, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of C5AR as well as pharmaceutical compositions comprising such compounds.