发明名称 |
Synthetic vaccine agents |
摘要 |
The present invention provides for novel immungens that are comprised of an activated polyhydroxypolymer backbone to which is attached 2 separate antigenic determinants. The 1st antigenic determinant includes a B-cell or CTL epitope and the 2nd antigenic determinant includes a T-helper epitope. In preferred embodiments, the antigenic determinants are derived from different molecules and species. Exemplary immunogens of the invention are constituted of a linear tresyl-activated dextran backbone to which is coupled B-cell or CTL epitopes of an antigen and to which is also coupled universal T-helper epitopes. Also disclosed are immunogenic compositions comprising the immunogens, methods of immunisation and a method for identification of suitable immunogens of the invention. |
申请公布号 |
US2004191264(A1) |
申请公布日期 |
2004.09.30 |
申请号 |
US20030643103 |
申请日期 |
2003.08.18 |
申请人 |
NIELSEN KLAUS GREGORIUS;KOEFOED PETER |
发明人 |
NIELSEN KLAUS GREGORIUS;KOEFOED PETER |
分类号 |
A61K39/02;A61K39/10;A61K39/385;(IPC1-7):A61K39/00;A61K39/38 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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