ANTHRANILIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS ANTIARRHYTHMIA AGENTS, AND PHARMACEUTICAL PREPARATIONS THEREOF

摘要

The relation relates to anthranilic acid amides, to a method for the production thereof, to their use as a medicament and to pharmaceutical preparations containing them. The compounds are therefore especially suited as antiarrhythmic active substances, particularly for treating and preventing atrial arrhythmias, e.g. atrial fibrillaion AF (atriale Fibrillation, AF) or atrial flutter (atriales Flattern). They act upon the Kv1.5 potassium channel and inhibit a potassium stream described as "ultra rapidly activated delayed rectifier" in the human cardiac atrium. The compounds have the formula wherein R1 to R 7 have the meaning given in the description. 15 claims