Inhibition of TNF-alpha-initiated neutrophil response

摘要

The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNFalpha)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1-10 nM, the LXA4 and ATL analogs each inhibited TNFalpha-stimulated superoxide anion generation and IL-1beta release by human PMN.