EFFECTIVE AND STABLE DNA ENZYMES

摘要

The invention relates to DNA enzymes of type 10-23, which are particularly stable as a result of modifications to particular nucleotides in the core sequence and furthermore have an essentially similar or improved cleaving efficiency for the substrate thereof, relative to the unmodified DNA enzyme. The invention further relates to host cells, containing said DNA enzymes. A medicament is also prepared which contains said DNA enzymes or said host cells. The DNA enzyme and further inventions are particularly targeted at the vanilloid receptor 1 (VR1) or picorna viruses. Small interference RNA molecules (siRNA) are also disclosed, targeted at VR1 and the host cells containing the siRNA. The siRNA and corresponding host cells are suitable as medicaments or for the production of medicaments, in particular for the treatment of pain and other disease states associated with VR1.