METHOD FOR PREPARING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To provide a method for preparing a trifluoromethyl-substituted 2-alkoxyacetophenone derivative which is an important intermediate of drugs and agrochemicals. SOLUTION: The trifluoromethyl-substituted 2-alkoxyacetophenone derivative is obtained by reacting a trifluoromethyl-substituted phenacyl halide with a water-containing lower alcohol solution under acidic or neutral conditions or by brominating a trifluoromethyl-substituted acetophenone with Br2in the presence of an alkylenediol to give a cyclic acetal of a trifluoromethyl-substituted phenacyl bromide and then reacting the cyclic acetal with a water-containing lower alcohol solution under acidic or neutral conditions. According to this method, the trifluoromethyl-substituted 2-alkoxyacetophenone derivative can be much more simply obtained than before. COPYRIGHT: (C)2004,JPO&NCIPI