发明名称 |
Protease resistant ti-growth hormone releasing hormone |
摘要 |
One aspect of the current invention is a composition for a modified growth hormone releasing hormone ("GHRH") or functional biological equivalent thereof. Another aspect of the current invention includes a nucleic acid molecule that encodes the modified GHRH or functional biological equivalent. The modified GHRH can be defined as a biologically active polypeptide that was engineered to contain a distinct amino acid sequence while simultaneously having similar or improved biologically activity when compared to a wild-type GHRH ("wt-GHRH") polypeptide. Another aspect of the current invention includes a method for delivering the composition of this invention to a subject, wherein the modified GHRH increases the level of growth hormone ("GH") secretion in a subject. The preferred subject is a human or domesticated animal. Additionally, the modified GHRH composition is resistant to degradation when compared to the wt-GHRH.
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申请公布号 |
US2004192593(A1) |
申请公布日期 |
2004.09.30 |
申请号 |
US20020166356 |
申请日期 |
2002.08.21 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
DRAGHIA-AKLI RUXANDRA;FIOROTTO MARTA L.;TAFFET GEORGE |
分类号 |
A61K38/00;A61K38/17;A61K48/00;C07K14/60;(IPC1-7):A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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