| 发明名称 |
SUBSTITUTED 4-PHENYL-4-CYANOCYCLOHEXANOIC ACID COMPOUND AND ITS PRODUCTION METHOD |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a production method of a compound which selectively depresses PDE IV(phosphodiesterase type IV). SOLUTION: The compound shown in formula (I) can be produced by applying to a series of reactions that a compound shown in formula (II) is reacted with lithium bromide or magnesium bromide at a high temperature of 60-100°C. COPYRIGHT: (C)2004,JPO&NCIPI
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| 申请公布号 |
JP2004269546(A) |
申请公布日期 |
2004.09.30 |
| 申请号 |
JP20040171346 |
申请日期 |
2004.06.09 |
| 申请人 |
SMITHKLINE BEECHAM CORP |
发明人 |
ALLEN ANDREW;DIEDERICH ANN MARIE;LIU LI;MENDELSON WILFORD |
| 分类号 |
A61P11/06;A61K31/277;C07B61/00;C07C253/30;C07C253/34;C07C255/31;C07C255/46;C07D303/48;(IPC1-7):C07C253/30 |
主分类号 |
A61P11/06 |
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