| 发明名称 |
CYTOTOXIC CD44 ANTIBODY IMMUNOCONJUGATES |
| 摘要 |
<p>The present invention relates to novel conjugates of antibodies with cytotoxic compounds, pharmaceutical compositions containing such conjugates, and their use in cancer therapy. In particular, the present invention relates to conjugates of antibodies which are specific for CD44 with maytansinoids, preferably with N2'-deacetyl-N2'(3-mercapto-1-oxopropyl)-maytansine (DM1). 37 claims, 5 figures</p> |
| 申请公布号 |
BG108366(A) |
申请公布日期 |
2004.09.30 |
| 申请号 |
BG20030108366D |
申请日期 |
2003.11.17 |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
ADOLF, GUENTER;HEIDER, KARL-HEINZ;PATZELT, ERIK;SPROLL, MARLIES |
| 分类号 |
C07D498/18;A61K31/5386;A61K31/787;A61K39/395;A61K47/48;A61P35/00;(IPC1-7):A61K47/48 |
主分类号 |
C07D498/18 |
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