发明名称 |
LIGANDS FOR TGF-BETA BINDING PROTEINS AND USES THEREOF |
摘要 |
Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta bindi ng protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.
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申请公布号 |
CA2519131(A1) |
申请公布日期 |
2004.09.30 |
申请号 |
CA20042519131 |
申请日期 |
2004.03.12 |
申请人 |
CELLTECH R & D, INC. |
发明人 |
SHPEKTOR, DIANA;WINKLER, DAVID G.;LATHAM, JOHN;SKONIER, JOHN;HAYES, TRENTON;GEOGHEGAN, JAMES |
分类号 |
A61K;A61K38/18;A61P19/00;C07K14/475;C07K14/51;C07K14/705;G01N33/53;G01N33/74;(IPC1-7):A61K38/18 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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