COMPOSITIONS AND METHODS FOR DETECTING AND TREATING NEURODEGENERATIVE PATHOLOGIES

摘要

The invention concerns compositions and methods for detecting and treating neurodegenerative pathologies. In particular it concerns the identification of novel metabolic paths and novel molecular targets involved in the development of neurodegenerative pathologies, and diagnostic and therapeutic techniques based on modulation of said paths or of the activity of said targets. The invention concerns in particular the presence, in affected patients, molecular modifications in the prostaglandin synthesis path PGD2 and enables development of efficient and specific therapeutic and diagnostic strategies. The invention also concerns methods, tools, constructs and compositions suitable for implementing said strategies.