发明名称 |
COMBINATION OF AN ALDOSTERONE RECEPTOR ANTAGONIST AND A NEUTRAL ENDOPEPTIDASE INHIBITOR |
摘要 |
Novel combinations, compositions, and therapeutic methods of treatment and/or prophylaxis of a hypertension, cardiovascular disease, renal dysfunction, edema, cerebrovascular disease, or insulinopathy pathological condition in a subject, wherein the methods comprise the administration of a combination of one or more aldosterone receptor antagonists and one or more NEP inhibitors; a combination of one or more aldosterone receptor antagonists, one or more NEP inhibitors, and one or more ACE inhibitors; or a combination of one or more aldosterone receptor antagonists and one or more vasopeptidase inhibitors selected from a specific group of compounds described herein. |
申请公布号 |
WO2004082636(A2) |
申请公布日期 |
2004.09.30 |
申请号 |
WO2004US08220 |
申请日期 |
2004.03.18 |
申请人 |
PHARMACIA CORPORATION;MCMAHON, ELLEN, G.;RUDOLPH, AMY, E. |
发明人 |
MCMAHON, ELLEN, G.;RUDOLPH, AMY, E. |
分类号 |
A61K31/56;A61K45/06 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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