发明名称 |
Mitochondrial genome replenishment |
摘要 |
The invention provides composition and methods for delivering a composition according to the invention comprising a wild-type (wt) mitochondrial DNA (mtDNA) molecule to a mammalian cell. The wt-mtDNA molecule is a functional mtDNA molecule that includes the entire mitochondrial genome. The wt-mtDNA molecule in the composition of the invention has a mitochondrial leader sequence (MLS) peptide attached to facilitate the uptake of the mtDNA molecule into a mitochondrion of the mammalian cell. The delivery of the wt-mtDNA/MLS peptide complex is used as a general replenishment therapy for conditions attributed to mtDNA defects, independent of the specific defect in the mtDNA.
|
申请公布号 |
US2004192627(A1) |
申请公布日期 |
2004.09.30 |
申请号 |
US20040485407 |
申请日期 |
2004.01.30 |
申请人 |
WEISSIG VOLKMAR;TORCHILIN VLADIMIR |
发明人 |
WEISSIG VOLKMAR;TORCHILIN VLADIMIR |
分类号 |
A61K48/00;C12N15/87;(IPC1-7):A61K31/70;A01N43/04;C12N15/00;C12N15/09;C12N15/63;C12N15/70;C12N15/74 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|