发明名称 |
METHODS AND COMPOSITIONS FOR TREATMENT OF MACULAR AND RETINAL DISEASE |
摘要 |
The present invention describes linking a therapeutic agent to a compound which is known to be naturally concentrated in a tissue affected by, or that is causing, a disease, to create a prodrug for treatment of the disease. Embodiments of the present invention include a new class of carotenoid-linked drugs to treat such blinding retinal disease such as age-related macular degeneration, retinoblastoma, and diabetic macular edema. For example, the present invention comprises a method for the treatment of a disorder of the eye comprising linking a therapeutic agent to a xanthophyll carotenoid to create a prodrug, and administering a therapeutically effective amount of the prodrug to an individual in need of treatment. Provided are prodrugs for treatment of retinoblastoma, cystoid macular edema (CME), exudative age-related macular degeneration (AMD), diabetic retinopathy, diabetic macular edema, or inflammatory disorders. |
申请公布号 |
WO2004016214(A3) |
申请公布日期 |
2004.09.30 |
申请号 |
WO2003US25229 |
申请日期 |
2003.08.13 |
申请人 |
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC.;MARCUS, DENNIS, MICHAEL;CHU, CHUNG, KWANG |
发明人 |
MARCUS, DENNIS, MICHAEL;CHU, CHUNG, KWANG |
分类号 |
A61K31/015;A61K31/07;A61K31/12;A61K31/35;A61K31/40;A61K31/405;A61K31/44;A61K31/497;A61K31/56;A61K47/48 |
主分类号 |
A61K31/015 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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