| 摘要 |
Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN-, (where X and Y are hydrogen or various groups); R<a >represents alkylene; R<b >and R<c >each represents alkylene, the total number of carbon atoms in said straight chains of R<b >and R<c >being 7); R<2 >and R<3 >each represents hydrogen, or a group of formula R, RCO-, ROCO-, or RNHCO-, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R<1 >represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event.
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