发明名称 MISMATCH RECOGNITION MOLECULE AND METHOD FOR DETECTING MISMATCH, AND USE OF THE MOLECULE
摘要 PROBLEM TO BE SOLVED: To obtain a compound capable of effectively recognizing a mismatch at least in cytosine-cytosine, to provide a method for detecting the mismatch using the compound, to provide a kit for use in the method, and to provide a method for detecting abnormality(ies) in a base sequence. SOLUTION: The compound is represented by formula(I)( wherein, X is N or CH; R<SB>1</SB>, R<SB>2</SB>and R<SB>3</SB>are each H or a 1-10C alkyl; R<SB>4</SB>and R<SB>5</SB>are each H or a 1-5C alkyl; wherein for each of the alkyl groups, the carbon atom(s) may be substituted with nitrogen atom(s), sulfur atom(s) or oxygen atom(s) or may have amino or carboxy group(s) ). This compound can form a pseudobase pair if there is a mismatch in at least cytosine-cytosine, therefore enabling the mismatch to be detected by detecting or assaying the formation of the pseudobase pair. COPYRIGHT: (C)2004,JPO&NCIPI
申请公布号 JP2004261083(A) 申请公布日期 2004.09.24
申请号 JP20030054700 申请日期 2003.02.28
申请人 JAPAN SCIENCE & TECHNOLOGY AGENCY 发明人 NAKATANI KAZUHIKO;KOBORI TETSUO
分类号 G01N33/53;C07D215/38;C07D471/04;C12N15/09;C12Q1/68;G01N33/566;G01N33/58;(IPC1-7):C12Q1/68 主分类号 G01N33/53
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