Heterocyclic sodium/proton exchange inhibitors and method

摘要

Heterocyclic compounds having the structure (I), which are sodium/proton exchange (NHE) inhibitors, and are useful as antianginal and cardioprotective agents are disclosed, wherein n is 1 to 5; X is N or C-R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl group, R1, R2, R3 and R4 are as defined in the specification, and where X is N, R1 is preferably aryl or heteroaryl. In addition, a method is described for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.