摘要 |
1H-pyrrolo[2,3-b]pyridines of formula (I) and their pharmaceutically acceptable salts that are useful for treating cell proliferative disorders associated with an altered cell cycle dependent kinase activity are disclosed, wherein R is a hydrogen or halogen atom or a group selected from -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, -(CH2)nNHCONR4R5, -(CH2)nNHCOOR4, or -(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R2 is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl.
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申请人 |
PHARMACIA ITALIA S |
发明人 |
LONGO, ANTONIO;BRASCA, MARIA GABRIELLA;ORSINI, PAOLO;TRAQUANDI, GABRIELLA;PITTALA, VALERIA;VULPETTI, ANNA;VARASI, MARIO;PEVARELLO, PAOLO |